Impacto clínico de la capilaroscopia periungueal en la práctica clínica diaria / Clinical impact of nailfold capillaroscopy in daily clinical practice

Introducción: La capilaroscopia periungueal (CP) es útil en la evaluación del fenómeno de Raynaud tanto primario como secundario, y en el seguimiento de los pacientes con esclerosis sistémica. Nuestro estudio evalúa el impacto de la CP en el diagnóstico, en función del motivo de solicitud y el perfil de autoanticuerpos en la práctica clínica diaria. Material y métodos: Se incluyeron todos los pacientes con al menos una CP entre junio de 2012 y diciembre de 2017. Se revisaron las historias clínicas y se determinó de forma dicotómica (sí/no) si la CP contribuyó al diagnóstico realizado en la consulta posterior a la realización de la CP. Se recogieron datos demográficos, clínicos y de laboratorio, motivo de solicitud de la CP y su relación con los patrones CP. Resultados: De 530 pacientes con una primera CP, 266 se realizaron como estudio de un fenómeno de Raynaud. De estos, en 20 pacientes (3,8%) se realizó un diagnóstico de enfermedad del tejido conectivo en la consulta posterior a la CP; 15 fueron diagnosticados de esclerosis sistémica, 4 de conectivopatía indiferenciada y uno de enfermedad mixta. Salvo un paciente diagnosticado de conectivopatía indiferenciada, el resto tenía anticuerpos antinucleares positivos y 11 de ellos, además, anticuerpos específicos (9 anticentrómero, uno anti-Scl70 y otro, anti-RNPC). La positividad de anticuerpos antinucleares se asoció con una mayor probabilidad de presentar una CP de esclerodermia, y ningún paciente diagnosticado de una enfermedad reumática tras la CP tenía un patrón normal. Conclusión: La CP es una técnica útil, pero con impacto limitado en el diagnóstico de enfermedades del tejido conectivo. La positividad de los anticuerpos se relaciona con una mayor probabilidad de presentar patrones patológicos en la CP.(AU)

Introduction: Nailfold capillaroscopy (NC) is useful in the evaluation of Raynaud's phenomenon, associated with some connective tissue diseases and in the follow-up of patients with systemic sclerosis. Our study evaluates the impact of NC in the diagnosis, according to the reason for the request and profile of autoantibodies in daily clinical practice. Material and methods: All patients that undergone at least one NC between June 2012 and December 2017 were included. Clinical records were reviewed and analysed in a dichotomous way (yes/no), to see whether the NC contributed to a change of diagnosis in subsequent consultations. In addition, demographic, clinical and laboratory data were collected, and the relationship with NC patterns evaluated. Results: Of the 530 patients who had undergone at least one NC, 266 had Raynaud's phenomenon as primary indication for the technique. Of those, 20 patients (3.8%) had a diagnostic change in the post-NC consultation; 15 were diagnosed with systemic sclerosis, 4 with undifferentiated connective tissue disease and one with mixed connective tissue disease. All patients had, except for one patient diagnosed with undifferentiated connective tissue disease, positive antinuclear antibodies titres, 11 of them had disease specific antibodies (9 anti-centromere, one anti-Scl70 and other anti-RNPC). The positivity of antinuclear antibodies titres was associated with a higher probability of presenting a scleroderma pattern in the NC, and all patients with a specific rheumatological diagnosis had an abnormal NC. Conclusion: NC is a useful technique, but with limited impact in the diagnosis of connective tissue diseases. Autoantibody positivity is associated with a greater likelihood of presenting pathological NC patterns.(AU)

Clinical impact of nailfold capillaroscopy in daily clinical practice. / Impacto clínico de la capilaroscopia periungueal en la práctica clínica diaria.

INTRODUCTION: Nailfold capillaroscopy (NC) is useful in the evaluation of Raynaud's phenomenon, associated with some connective tissue diseases and in the follow-up of patients with systemic sclerosis. Our study evaluates the impact of NC in the diagnosis, according to the reason for the request and profile of autoantibodies in daily clinical practice. MATERIAL AND METHODS: All patients that undergone at least one NC between June 2012 and December 2017 were included. Clinical records were reviewed and analysed in a dichotomous way (yes/no), to see whether the NC contributed to a change of diagnosis in subsequent consultations. In addition, demographic, clinical and laboratory data were collected, and the relationship with NC patterns evaluated. RESULTS: Of the 530 patients who had undergone at least one NC, 266 had Raynaud's phenomenon as primary indication for the technique. Of those, 20 patients (3.8%) had a diagnostic change in the post-NC consultation; 15 were diagnosed with systemic sclerosis, 4 with undifferentiated connective tissue disease and one with mixed connective tissue disease. All patients had, except for one patient diagnosed with undifferentiated connective tissue disease, positive antinuclear antibodies titres, 11 of them had disease specific antibodies (9 anti-centromere, one anti-Scl70 and other anti-RNPC). The positivity of antinuclear antibodies titres was associated with a higher probability of presenting a scleroderma pattern in the NC, and all patients with a specific rheumatological diagnosis had an abnormal NC. CONCLUSION: NC is a useful technique, but with limited impact in the diagnosis of connective tissue diseases. Autoantibody positivity is associated with a greater likelihood of presenting pathological NC patterns.

Cesárea electiva y parto vaginal en cesareadas previas: comparación de complicaciones maternoneonatales / Cesarean section and vaginal delivery in women with previous cesarean section: comparing maternal and neonatal outcomes

Describir las complicaciones maternoneonatales en cesárea electiva y parto vaginal en cesareadas previas. Diseño: Estudio descriptivo tipo serie de casos. Institución: Servicio de Obstetricia, Hospital Nacional Cayetano Heredia. Participantes: Pacientes con antecedente de cesárea. Intervenciones: Se incluyó en el estudio 1 591 pacientes con antecedente de cesárea atendidas entre el 1 de enero de 2001 y el 31 de diciembre de 2009. Se obtuvo los datos del Sistema Informático Perinatal (SIP), de la planilla de egresos hospitalarios 2001-2009, historias clínicas y libros de egreso de Banco de Sangre. Principales medidas de resultados: Complicaciones maternoneonatales derivadas de la cesárea. Resultados: La tasa de partos vaginales en pacientes con antecedente de cesárea fue 19%, y 81% de pacientes fue sometida a nueva cesárea. Hubo 18 casos de endometritis y 3 de infección de herida operatoria en el grupo de cesareadas a repetición, en contraste con dos casos de endometritis y ningún caso de infección de herida operatoria en el grupo de parto vaginal. Hubo pocos casos de Ápgar bajo y ninguno de muerte neonatal. Conclusiones: El porcentaje de complicaciones maternoneonatales fue similar en ambos grupos.

Objectives: To determine maternal and perinatal outcomes in a new cesarean procedure and vaginal delivery in women with prior cesarean delivery. Design: Descriptive, series of cases study. Setting: Obstetrics Service, Hospital Nacional Cayetano Heredia, Lima, Peru. Participants: We included 1 591 patients who had prior cesarean delivery between January 1, 2001 and December 31, 2009. We used the Perinatal Information System, clinical charts and Blood Unit registry. Main outcome measures: Maternal and neonatal complications associated with cesarean section. Results: The rate of vaginal deliveries and cesarean deliveries in women with prior cesarean delivery were respectively 19% and 81%. We found 18 endometritis cases and 3 infections of the operative wound in the group of cesarean deliveries, and two endometritis and no infections in the vaginal birth group. There were few cases of low Apgar and no neonatal death. Conclusions: The percentage of maternal and neonatal complications was similar in both groups.